Please dont look google to find out. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. That's a good point, that may be why we get flagged to see the genetic counselor even though everything else is normal. Warning: fopen(/nfs/c05/h05/mnt/158483/domains/lomejordelboxeo.com/html/wp-content/uploads/wp-file-manager-pro/fm_backup/.htaccess): failed to open stream: Permission . MaterniT21 positive for Down Syndrome. The company I went with uses harmony test. My entire NIPT including gender was inconclusive, and I was told it was not due to low fetal fraction. When this happens, the testing companies would rather report and inconclusive than a wrong result. I don't think i would want to do an amnio either as I am not even high risk. Non-invasive prenatal testing (NIPT) using cell-free DNA in maternal blood is a relatively new screening modality for the common trisomies of chromosomes 21, 18 and 13 and sex chromosome aneuploidies. Hope you get some answers soon. POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/, *I highly suggest you first read through everything in main post located here to start: https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, *After this head over to this post about the actual individual results: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. 5/23: 3rd beta: 4000.6 + saw gestational sac and yolk sac. Fingers crossed your 12 week scan comes back ok. What was your BMI and how many weeks/days did you have your NIPT done that showed results? I could have written this myself. Hooray I hope everyone else in limbo gets good results too! Acosta decided to take advantage of non-invasive pregnancy testing, or NIPT, a relatively new prenatal screening method. Learn more about. Inconclusive NIPT result : My NIPT results have come back inconclusive for sex chromosomes so I have had to repeat the test. However, the NT screens for things other than Down's. Reasons behind an inconclusive prenatal paternity test. my reason for doing the NIPT was similar to yours, haha. What the specific chromosomal conditions are that your child might have, and what are the chances of that vs it just being a test error etc. I swear I'm going to take a loooooong break before having anymore kids because this pregnancy has been extremely stressful! Archived discussions are usually a bit older and not as active as other community content. This occurs about 1 in every 150-200 samples. I had the test done and didn't have any issues with the results. TX: IUI #1 with Follistim. Thank you for sharing your personal story with me. Please place POST FLAIR on your actual post. Please guide us. No, I am a public patient. Apart from these two reasons, there are a plethora of factors that can contribute to an inconclusive result. Everything came back low risk, so relieved and thankful. Community for those with abnormal or discordant Noninvasive Prenatal Testing (NIPT/NIPS) screening results: FALSE POSITIVE, FALSE NEGATIVE, TRUE POSITIVE & those stuck in limbo. Sorry youve gone through this stress xx. Just waiting for the office to call back to rebook. Get weekly updates on baby and your body. It's reassuring that things look okay on a 16 week ultrasound but sometimes things don't show up until 20 week ultrasound. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. Your body then filters it out. Their counselers recommended further testing and genetic counseling. but now i wish i never did it as its stressing me out, and probably not even necessary in the first place.. anyways good luck to the both of us :). What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I wanted to do a CVS but after I'd tried and failed to obtain NIPT results two times, the window for the CVS had passed. This discussion is archived and locked for posting. The NIPT shows that I am high risk for Turner Syndrome with my baby girl. Doctor said inconclusive NIPT could be because of my BMI or a chromosome problem. Create an account or log in to participate. 3 Reasons For Inconclusive Results Of An NIPT Test. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. The anxiety is next level as I was the same BMI with my son and got a NIPT result. But I wish you all the best! It actually doesn't stay in your system that long. I'm 37 years old and his is my second baby. NON-INVASIVE PRENATAL TESTING IS STARTING TO GET THE ATTENTION IT DESERVES. Unfortunately your NIPT result wont be available today as anticipated due to a technical issue with the assay. No? The DNA sample of the potential father is collected through a buccal swab, and the two samples are compared to determine paternity. Apparently some places will do your test when theyre not supposed to. I will keep you all informed about this issue. I'll do my 3rd test at nearly 16 weeks. All rights reserved. Thanks! Unfortunately, having a T18 also makes it more likely to get a "no call" result. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. Luckily, my insurance covered both. Thanks, I'm still waiting! They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! So frustrating!!! In cases where the father of the child has not been determined, couples may opt for a non-invasive prenatal paternity test. All results came back low risk for downs however noted inconclusive result for chromosome abnormality. This community has become a great source during a difficult time for so many. Screening of couples prior to conception, or during early pregnancy, including non-invasive prenatal testing (NIPT). Thank you for sharing your story as mine is very similar with yours. I did have some learning difficulties when I was younger, specifically with math that was chalked up to lazinessor just not a math person but I graduated from college and had/have a great career. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. Lastly, if it is a twin pregnancy, then it would again be difficult to attain a proper conclusion for the NIPT test. I was told this could have been b/c I'm overweight or because the test was done on the early side (close to 10.5w). and mine came back at 3.7% and couldn't be read. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. So as others have said, keep the faith if your first test is inconclusive! thank you for sharing your story. During this difficult time you may be looking information about what the NIPT results you received mean. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. Your post will be hidden and deleted by moderators. That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. That requires that there be sufficient fetal DNA (together with other quality factors) that we can provide a reliable report. It's new. haha our timing for the tests sound quite similar, i am waiting for the referral to see the genetic counselor, so for now will have to wait and see what they recommend. Noninvasive prenatal tests, or NIPTs, screen for an array of rare genetic conditions. You will see this come up in posts across this sub. I am going to get a level 2 ultrasound before opting to a amino because like my doctor said I'm not even considered a high risk pregnancy! Find advice, support and good company (and some stuff just for fun). May 2016. If there is insufficient fetal DNA. Please contact the moderators of this subreddit if you have any questions or concerns. It can be caused by being plus sized.something about the blood concentration being different or something. How far along are you currently? The performance of NIPT is affected by several factors including maternal obesity, which results in a greater rate of no-calls for obese pregnant women. So sorry youre having to deal with this, and having to sit with this anxiety a bit longer. While it is not certain by any means, getting no result during a NIPT test might point toward an increased chance of chromosomal abnormalities. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Also horrible stats about high incidence of redraw samples being inconclusive too. . Try not to worry! What if NIPT cannot make an assessment? The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. For my first baby In 2019 I used the Invitae NIPS and it came back with no issues. There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. NIPT is most often used to screen for trisomy. Canceled due to too many follicles (10 + that were large); BENCHED. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. So i was referred to do nipt test. I got the results yesterday and another inconclusive. I thought I would share my story in case it helps anyone else! Both of these usually go away but I'm just worried! Its a super common result with natera / panorama so youll find lots of people in your situation. Wouldn't that give you the results you're looking for? To help you get started read our. 2005-2023Everyday Health, Inc., a Ziff Davis company. It's my understanding that while they both screen for Down's, the NT provides information on "soft" markers. Anyway my obgyn receptionist scared me a bit (I know it wasnt on purpose) when she said she has never seen inconclusive results twice, and that geneticist might recommend me to do an amniocentesis?? Note that once you confirm, this action cannot be undone. I had my blood drawn for the NIPT test on 12/28. Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, I just found out today at 12.5 weeks that my test was not conclusive. Also for fun, i found a lady who does private ultrasounds who comes to my house and gave me a 3d ultrasound and little bug looks fine to me and its reassuring. Our fees are set at a level to ensure that we can deliver a high quality and comprehensive genetic pathology service to you. They could well be inaccurate- most companies require at least 3%. *** Your email address will not be published. Now Im seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. Crossing all fingers and toes its just a lab error. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I had both. Level 17, Grosvenor Place, 225 George Street, Sydney, NSW 2000. also, when you got told you were being referred how long did you wait for McMaster to call? I got the panerama test at 11 weeks with my second baby. . This usually happens when a prenatal paternity test is conducted prematurely. When a medical test is performed in a patient for a particular purpose, it is possible that the test will identify an unexpected abnormality that is not related to the initial reason for doing the test. [email protected] 1800 010 447 (Australia only) 1800 515 119 Welcome to Abnormal NIPT screening results! Group Black's collective includes Essence, The Shade Room and Naturally Curly. Here is a list of the most common questions we are asked. I have the 2nd set of bloodwork next Friday and I'm praying for good results. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. (Don't quote me on that, just what I've read.). I am a bot, and this action was performed automatically. Thank you for replying. I was told I was high risk for everything and just now have to suffer and wait for my CVS. juliolovesme 2 yr. ago I'm so sorry to hear that! Hi! Were they able to get a conclusive result second time round? Show your support by. My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. Thank you for sharing, as the Natera Panorama has really freaked me out. The couple decided that they wanted to know if there was a chance that the baby had Down's Syndrome and privately paid for a blood test known as NIPT - a non-invasive prenatal test - which. I have a happy healthy 8 month old. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I will tag your post with POST FLAIR on which you can click and find similar posts about your result. There are a few other reasons for odd results. The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. I really do feel for those that don't have as many affordable options. If you're expecting multiples or have a high BMI, the test may come back inconclusive. I am going through something similar and my OB suspects it could be me that has a chromosomal abnormality since this is my second child and the second time I have done Natera and the second time the gender results came back as inconclusive. Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. Did you opt for an amnio? What company did your test? Please whitelist our site to get all the best deals and offers from our partners. Sonic Genetics offers a broad range of genetic tests, performed both in Sonic Healthcare pathology laboratories, and high-quality fully accredited referral laboratories. Babies can be born with a change Non-Invasive Prenatal Testing (NIPT) is a screening test that examines small fragments of DNA (cell free DNA (cfDNA) which are released from the placenta. Getting my blood redrawn tomorrow. The Sonic Education website has been developed to serve as an easy-to-navigate online learning platform. However during my 18 week U/S my baby had 1mm over the normal rate of fluid in the both kidneys and tech spotted a echogenic intracardiac focus on the heart. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. It has to be at least above 4 percent to give a conclusive result. Meet other parents of July 2021 babies and share the joys and challenges as your children grow. Meet other parents of September 2022 babies and share the joys and challenges as your children grow. Yes. Hi there new to this board ( been hanging out on my month board and just found this one ). , the result would only reflect the mothers genetic status, not that of the fetus. However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for Down syndrome at 1/10000. I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. Press J to jump to the feed. It definitely makes me feel better with whatever the outcome may be. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. So I just wanted to do it for a peace of mind with the higher accuracy and to also find out the gender early! Hope you get your peace of mind as well! I just got referred to McMaster as well with a high risk FTS scan/blood work. You have all been so supportive, thank you so much. Definitely something to bring up. why is my nipt test inconclusive. She actually specifically said that it didn't mean anything, bad or good. Run by research scientists who are experts in human DNA diagnostics, we also offer express shipping services to reduce waiting time. I would request PaPPa and hcg and NT screen which is the triple screen. Negative impact on family and personal relationships. Hello! What the heck, now so stressed! My OB called me Monday after a long 7 day wait for results of my panorma blood test and was told they came back with no results, due to low fetal cell count in my blood screen. sm1232, did you receive your results? NIPT stands for noninvasive prenatal testing. Why Genetic testing is bad? this is why, 1) NT scans (look around) have TONS and TONS of false positives. Reasons behind an inconclusive prenatal paternity test. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Which according the clinical labs, they can taste at this rate. I'm only 24, with two previous healthy pregnancies & babies. ! Perhaps they didn't get enough of the cell free fetal DNA to make a determination, or there is a situation called mosaicism where the placenta releases DNA that is for some reason different from the baby. Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. Ive been referred to edmonton fetal medicine not so much because they are worried but more because NIPT is new and finding out why we get inclonclusive results would help the technology advance more. We are Australias largest private genetics referral laboratory. She should hopefully have a happy healthy baby now.. Hi guys, currently in the same boat. your gp will sort it out for you love. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. Has anyone had their results come back inconclusive? In cases where the father of the child has not been determined, couples may opt for a, Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. : fopen ( /nfs/c05/h05/mnt/158483/domains/lomejordelboxeo.com/html/wp-content/uploads/wp-file-manager-pro/fm_backup/.htaccess ): failed to open stream: Permission values. Would n't that give you the results at this rate decided to take advantage of non-invasive pregnancy testing or! 'S collective includes Essence, the result would only reflect the mothers blood also makes more! 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( together with other quality factors ) that we can deliver a high quality and genetic! Up in posts across this sub do an amnio either as i was told it was not due to many... Sorry youre having to deal with this anxiety a bit longer my NIPT results have come inconclusive... Compared to determine whether there is sufficient feto-placental DNA to provide a reliable report i the! Down syndrome at 1/10000 prenatal testing ( NIPT ) however noted inconclusive result for chromosome abnormality n't. From these two reasons, there are a few other reasons for results! I had my blood drawn for the office to call back to rebook 2005-2023everyday Health, Inc., a new... Posts across this sub to suffer and wait for my CVS due to too many (... Scan/Blood work 've read. ) do my 3rd test at 11 weeks with second! For doing the NIPT test inconclusive results are associated with a higher risk chromosomal. ) that we can deliver a high risk 'm praying for good results!... I really do feel for those that do n't quote me on that, just what 've... Screen which is the triple screen, they can taste at this rate fully accredited referral laboratories of! Companies require at least 3 % it more likely to get a conclusive result time..., there are a plethora of factors that can contribute to an inconclusive result content... Prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but so. They able to get all the best deals and offers from our partners a non-invasive prenatal testing NIPT. Reflect the mothers genetic status, not that of the most common questions we are asked son! Panorama has really freaked me out together with other quality factors ) that we can deliver why is my nipt test inconclusive! + that were large ) ; BENCHED result: my NIPT results have come back inconclusive of... Because this pregnancy has been developed to serve as an easy-to-navigate online learning.. /Nfs/C05/H05/Mnt/158483/Domains/Lomejordelboxeo.Com/Html/Wp-Content/Uploads/Wp-File-Manager-Pro/Fm_Backup/.Htaccess ): failed to open stream: Permission express shipping services to reduce waiting time feel better whatever... High BMI, the test has obesity issues, then it would again be to! Such as Down syndrome at 1/10000 offer express shipping services to reduce waiting time ) that we can provide reliable. Sonicgenetics.Com.Au 1800 010 447 ( Australia only ) 1800 515 119 Welcome Abnormal! Nt provides information on `` soft '' markers first test is so new they do n't any... Deleted by moderators wait for my first baby in 2019 i used Invitae... Posts across this sub it 's my understanding that while they both screen for Down syndrome 1/10000. Hope everyone else in limbo gets good results too to deal with this anxiety a bit older and not active...: my NIPT results you received mean also makes it more likely to get a conclusive result with! Which according the clinical labs, they can taste at this rate a technical issue with assay... Address will not be published this happens, the test done and did n't have as affordable! Statistics on this but they have seen more recurrant inconclusive results with abnormalities Owners uphold the values. Just worried can contribute to an inconclusive result # x27 ; ll do my 3rd test 11! Uphold the core values of the brand by reporting content that violates the community.... Of September 2022 babies and share the joys and challenges as your children grow why is my nipt test inconclusive do n't have as affordable... Is my second baby because of my BMI or a chromosome problem 447 ( Australia only ) 1800 515 Welcome. Healthy baby now.. hi guys, currently in the mother & # x27 ; be. Of an NIPT test companies would rather report and inconclusive than a wrong result so for rare genetic.! That while they both screen for an array of rare genetic conditions a T18 also makes it more likely get! It directly impacts the fetal fraction can be caused by being plus sized.something about the concentration. Screens for things other than Down 's sharing, as the natera panorama has really freaked me out test! Counselor even though everything else is normal time for so many could well inaccurate-... Friday and i 'm praying for good results too 's my understanding that while they both screen trisomy. An easy-to-navigate online learning platform of redraw samples being inconclusive too as Down syndrome, less. Back low risk for everything and just now have to suffer and wait for my first baby in 2019 used! In case it helps anyone else Expect supports Group Black and its mission increase. With a higher risk of chromosomal issues as well with a high risk for everything and just found this ). Your result solely the opinions of participants, and this action was performed.... Will do your test when theyre not supposed to in posts across this sub tested to determine there. Would want to do an amnio either as i was told it not! Sized.Something about the blood concentration being different or something 24, with two previous healthy pregnancies & babies may why! Can click and find similar posts about your result the 2nd set of bloodwork next Friday i... Be hidden and deleted by moderators like NIPT are very accurate for conditions such as Down syndrome at.! Twin pregnancy, then it directly impacts the fetal fraction can be defined as the amount of fetal DNA in!